Hemisphericity refers to a preference for using one hemisphere of the brain over the other hemisphere to have stronger control over some functions of the mind and body. The Present study investigated the Brain Hemisphericity of Higher Secondary school students in Chennai. Survey method has been used and Stratified Random Sampling technique was adopted. To achieve the purpose of the study, a sample of 550 Higher Secondary School Students were selected. The study reveals that there is a significant difference between Brain Hemisphericity with respect to their Management of School.