A Review on the Relevance of Curcuminoids in Corona Pandemic Situation

Abstract

A hyperactive response by the immune system is said to be primarily responsible for pneumonia, also a fallout of a severe SARS-CoV-2 infection. Infection starts when the viral spike protein binds to its complementary host cell receptor. Viruses from the corona primarily attack epithelial cells. Depending on the species of the coronavirus, they are transmitted from one host to another by either an aerosol, fomite, or faecal-oral route. Chloroquine and hydroxychloroquine are interferon blockers but they increase the risk of unsafe heart rhythm disturbances. Curcumin, a phytochemical which occurs naturally in Curcuma longa, is known to have strong pharmacological properties. But it is essential to overcome the limitations for using it in medication. By docking, curcumin and its derivatives were shown to have the capacity to serve as spike protein inhibitors and thus viral entry. In this review, papers focused on the structure, platforms, and ill effects of coronavirus, and also disclose the nutrients which include mainly polyphenols and antioxidants containing curcuminoids which have antiviral and anti-inflammatory properties; the nutrients under discussion can support the healthy functioning and strengthening of the respiratory system.